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Targeted Allele Detail
Symbol: Stat3tm2Vpo
Name: signal transducer and activator of transcription 3; targeted mutation 2, Valeria Poli
MGI ID: MGI:3040152
Synonyms: Stat3deltaalpha
Gene: Stat3  Location: Chr11:100886806-100939594 bp, - strand  Genetic Position: Chr11, 63.82 cM
Germline Transmission:  Earliest citation of germline transmission: J:89194
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsTo generate an allele in which the expression of the alpha isoform is completely ablated while the expression of the beta isoform is maintained, cDNA encoding the C-terminal of the beta isoform, as well as a polyA-neo cassette, was inserted into exon 20. RT-PCR and Western blot analyses of homozygous mutant liver confirmed the absence of the alpha isoform. Comparisions with the level of alpha isoform transcript and protein in wild-type mice indicated that while the level of beta isoform transcript is equivalent, the level of beta isoform protein is reduced. (J:89194)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stat3 Mutation:  35 strains or lines available
Original:  J:89194 Maritano D, et al., The STAT3 isoforms alpha and beta have unique and specific functions. Nat Immunol. 2004 Apr;5(4):401-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory