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Targeted Allele Detail
Symbol: Stat3tm2Vpo
Name: signal transducer and activator of transcription 3; targeted mutation 2, Valeria Poli
MGI ID: MGI:3040152
Synonyms: Stat3deltaalpha
Gene: Stat3  Location: Chr11:100885098-100939540 bp, - strand  Genetic Position: Chr11, 63.82 cM
Germline Transmission:  Earliest citation of germline transmission: J:89194
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Disruption caused by insertion of vector
Mutation detailsTo generate an allele in which the expression of the alpha isoform is completely ablated while the expression of the beta isoform is maintained, cDNA encoding the C-terminal of the beta isoform, as well as a polyA-neo cassette, was inserted into exon 20. RT-PCR and Western blot analyses of homozygous mutant liver confirmed the absence of the alpha isoform. Comparisions with the level of alpha isoform transcript and protein in wild-type mice indicated that while the level of beta isoform transcript is equivalent, the level of beta isoform protein is reduced. (J:89194)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stat3 Mutation:  43 strains or lines available
Original:  J:89194 Maritano D, et al., The STAT3 isoforms alpha and beta have unique and specific functions. Nat Immunol. 2004 Apr;5(4):401-9
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.05
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