Tg(Dll1)19Gos
Transgene Detail

Summary

• Symbol: Tg(Dll1)19Gos
• Name: transgene insertion 19, Achim Gossler
• MGI ID: MGI:3038950
• Synonyms: msd::Dll1^dn
• Transgene: Tg(Dll1)19Gos Location: unknown
• Alliance: Tg(Dll1)19Gos page

Transgene origin

• Strain of Origin: (BALB/c x C57BL/6)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Dll1)19Gos expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Dll1 (MGI:104659)

• Mutation details: A modified mouse Dll1 cDNA encoding a truncated protein, lacking the majority of the intracellular domain, was adjoined to Dll1 regulatory sequence modified to contain 1494 bp of the 'msd' promoter fused to the minimal promoter and the 5' portion of exon 1 up to the start codon. The construct also contained an SV40 3' UTR and polyA signal. The protein is expected to lack 141 C-terminal residues, leaving only 12 intracellular residues adjacent to the transmembrane domain. Expression was detected in the posterior presomitic mesoderm and in newly formed somites with a gap of expression in the anterior presomitic mesoderm corresponding to S-I/S0. (J:88580)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:88580 Cordes R, et al., Specification of vertebral identity is coupled to Notch signalling and the segmentation clock. Development. 2004 Mar;131(6):1221-33
• All: 1 reference(s)