About   Help   FAQ
Targeted Allele Detail
Symbol: Lrattm1Kpal
Name: lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase); targeted mutation 1, Krzysztof Palczewski
MGI ID: MGI:3038935
Synonyms: Lrat-
Gene: Lrat  Location: Chr3:82799889-82811281 bp, - strand  Genetic Position: Chr3, 36.81 cM
Severe retinal degeneration in Rhotm2.1Kpal/Rhotm2.1Kpal Gnat1tm1Clma/Gnat1tm1Clma mice and less severe degeneration in Rhotm2.1Kpal/Rhotm2.1Kpal Lrattm1Kpal/Lrattm1Kpal mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:88871
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsPart of exon 1, including ATG, was replaced by a neo cassette via homologous recombination. Protein expression was abolished in the eye of homozygous mutant mice as shown by immunocytochemistry. Western blot shows no protein in homozygous mutants. (J:88871)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 7 assay results
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lrat Mutation:  19 strains or lines available
Original:  J:88871 Batten ML, et al., Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver. J Biol Chem. 2004 Mar 12;279(11):10422-32
All:  49 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.17
The Jackson Laboratory