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Il1rntm1Nick
Targeted Allele Detail
Nomenclature
Symbol: Il1rntm1Nick
Name: interleukin 1 receptor antagonist; targeted mutation 1, Martin J H Nicklin
MGI ID: MGI:3038876
Synonyms: Il1rn-
Gene: Il1rn  Location: Chr2:24336853-24351494 bp, + strand  Genetic Position: Chr2, 16.36 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:59410
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsHomologous recombination was used to fuse a vector containing the aph gene driven by a beta actin promoter with the ORF at exon 3, which encodes the single folding domain. This is codon 77 in the secreted form of the endogenous protein or codon 82 of the intact cell form. RT-PCR revealed that no transcript was found in mutant peritoneal macrophages. (J:59410)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Il1rn Mutation:  10 strains or lines available
References
Original:  J:59410 Nicklin MJ, et al., Arterial inflammation in mice lacking the interleukin 1 receptor antagonist gene. J Exp Med. 2000 Jan 17;191(2):303-12
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory