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Il7rtm1Iku
Targeted Allele Detail
Nomenclature
Symbol: Il7rtm1Iku
Name: interleukin 7 receptor; targeted mutation 1, Koichi Ikuta
MGI ID: MGI:3038693
Synonyms: 7Ralpha-, Il-7R-
Gene: Il7r  Location: Chr15:9506161-9529876 bp, - strand  Genetic Position: Chr15, 4.16 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:34658
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsHomologous recombination was used to replace exon 2, containing a conserved cysteine motif, with a neo cassette. RT-PCR revealed a shorter transcript in homozygous mutants than that of wild-type mice, putatively lacking exon 2 and resulting in a frame shift mutation. Flow cytometry indicated an absence of protein surface expression on homozygous spleen cells. (J:34658)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il7r Mutation:  6 strains or lines available
References
Original:  J:34658 Maki K, et al., Interleukin 7 receptor-deficient mice lack gammadelta T cells. Proc Natl Acad Sci U S A. 1996 Jul 9;93(14):7172-7
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory