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Aspatm1Mata
Targeted Allele Detail
Nomenclature
Symbol: Aspatm1Mata
Name: aspartoacylase; targeted mutation 1, Reuben Matalon
MGI ID: MGI:3038539
Synonyms: CD
Gene: Aspa  Location: Chr11:73304987-73326876 bp, - strand  Genetic Position: Chr11, 45.28 cM, cytoband B4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89100
Parent Cell Line:  Lex-1 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe gene was disrupted by the insertion of an IRES Beta-geo with a 10 bp deletion in exon 4 of Aspa. Beta-galactosidase expression under control of the Aspa promoter is maintained in the mutant allele. (J:89100)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aspa Mutation:  12 strains or lines available
References
Original:  J:89100 Matalon R, et al., Knock-out mouse for Canavan disease: a model for gene transfer to the central nervous system. J Gene Med. 2000 May-Jun;2(3):165-75
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory