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Pappatm1Cac
Targeted Allele Detail
Nomenclature
Symbol: Pappatm1Cac
Name: pregnancy-associated plasma protein A; targeted mutation 1, Cheryl Conover
MGI ID: MGI:3037868
Synonyms: Pappa-
Gene: Pappa  Location: Chr4:65124174-65357509 bp, + strand  Genetic Position: Chr4, 34.14 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:88578
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neo cassette replaced 1.6 kb of the gene including most of exon 4. RT-PCR confirmed lack of expression and IGFBP4 proteolysis confirmed lack of Pappa activity in homozygous mutants. (J:88578)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 17 assay results
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pappa Mutation:  3 strains or lines available
References
Original:  J:88578 Conover CA, et al., Metalloproteinase pregnancy-associated plasma protein A is a critical growth regulatory factor during fetal development. Development. 2004 Mar;131(5):1187-94
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory