Pappa^tm1Cac
Targeted Allele Detail

Summary

• Symbol: Pappa^tm1Cac
• Name: pregnancy-associated plasma protein A; targeted mutation 1, Cheryl Conover
• MGI ID: MGI:3037868
• Synonyms: Pappa^-, PAPP-A KO
• Gene: Pappa Location: Chr4:65042411-65275746 bp, + strand Genetic Position: Chr4, 34.14 cM
• Alliance: Pappa^tm1Cac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88578
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced 1.6 kb of the gene including most of exon 4. RT-PCR confirmed lack of expression and IGFBP4 proteolysis confirmed lack of Pappa activity in homozygous mutants. (J:88578)

Expression

In Mice Carrying this Mutation:	17 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Pappa^tm1Cac

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pappa Mutation: 71 strains or lines available

References

• Original: J:88578 Conover CA, et al., Metalloproteinase pregnancy-associated plasma protein A is a critical growth regulatory factor during fetal development. Development. 2004 Mar;131(5):1187-94
• All: 21 reference(s)