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Targeted Allele Detail
Symbol: Ccr10tm1Cge
Name: chemokine (C-C motif) receptor 10; targeted mutation 1, Craig Gerard
MGI ID: MGI:3036706
Synonyms: CCR10 -
Gene: Ccr10  Location: Chr11:101172998-101175443 bp, - strand  Genetic Position: Chr11, 64.34 cM
Germline Transmission:  Earliest citation of germline transmission: J:69621
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsThe first ATG codon of the gene was mutated to an EcoRV site, with an enhanced GFP gene and a neomycin resistance cassette being inserted into the EcoRV site. Gene inactivation was confirmed by a lack of product from RT-PCR of Peyer's patch RNA. GFP expression was observed in B cells expressing IgA, and in other leukocyte subsets including neutrophils. (J:69621, J:140728)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ccr10 Mutation:  10 strains or lines available
Original:  J:69621 Bhat MA, et al., Axon-glia interactions and the domain organization of myelinated axons requires neurexin iv/caspr/paranodin. Neuron. 2001 May;30(2):369-83
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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