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Targeted Allele Detail
Symbol: Fbxw7tm1Kin
Name: F-box and WD-40 domain protein 7; targeted mutation 1, Kei-ichi Nakayama
MGI ID: MGI:3036571
Synonyms: Fbw7-
Gene: Fbxw7  Location: Chr3:84815268-84979198 bp, + strand  Genetic Position: Chr3, 37.7 cM, cytoband E3.3
Vascular abnormalities in Fbxw7tm1Kin/Fbxw7tm1Kin embryos

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:88517
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 15 kb genomic fragment containing exons 1 through 5, which encode the N-terminal and F-box domains of the protein, was replaced by a floxed neo cassette. mRNA was undetected by in situ hybridization of homozygous mutant embryos. (J:88517)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fbxw7 Mutation:  48 strains or lines available
Original:  J:88517 Tsunematsu R, et al., Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development. J Biol Chem. 2004 Mar 5;279(10):9417-23
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.06
The Jackson Laboratory