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Fbxw7tm1Kin
Targeted Allele Detail
Summary
Symbol: Fbxw7tm1Kin
Name: F-box and WD-40 domain protein 7; targeted mutation 1, Kei-ichi Nakayama
MGI ID: MGI:3036571
Synonyms: Fbw7-
Gene: Fbxw7  Location: Chr3:84722575-84886505 bp, + strand  Genetic Position: Chr3, 37.7 cM, cytoband E3.3
Alliance: Fbxw7tm1Kin page
Vascular abnormalities in Fbxw7tm1Kin/Fbxw7tm1Kin embryos

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:88517
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 15 kb genomic fragment containing exons 1 through 5, which encode the N-terminal and F-box domains of the protein, was replaced by a floxed neo cassette. mRNA was undetected by in situ hybridization of homozygous mutant embryos. (J:88517)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Fbxw7tm1Kin
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fbxw7 Mutation:  82 strains or lines available
References
Original:  J:88517 Tsunematsu R, et al., Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development. J Biol Chem. 2004 Mar 5;279(10):9417-23
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory