About   Help   FAQ
Fbxw7tm1Kin
Targeted Allele Detail
Nomenclature
Symbol: Fbxw7tm1Kin
Name: F-box and WD-40 domain protein 7; targeted mutation 1, Kei-ichi Nakayama
MGI ID: MGI:3036571
Synonyms: Fbw7-
Gene: Fbxw7  Location: Chr3:84815268-84979198 bp, + strand  Genetic Position: Chr3, 37.7 cM, cytoband E3.3
Vascular abnormalities in Fbxw7tm1Kin/Fbxw7tm1Kin embryos

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:88517
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 15 kb genomic fragment containing exons 1 through 5, which encode the N-terminal and F-box domains of the protein, was replaced by a floxed neo cassette. mRNA was undetected by in situ hybridization of homozygous mutant embryos. (J:88517)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fbxw7 Mutation:  54 strains or lines available
References
Original:  J:88517 Tsunematsu R, et al., Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development. J Biol Chem. 2004 Mar 5;279(10):9417-23
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/11/2017
MGI 6.10
The Jackson Laboratory