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Tcf4tm1Hmb
Targeted Allele Detail
Nomenclature
Symbol: Tcf4tm1Hmb
Name: transcription factor 4; targeted mutation 1, Dan Holmberg
MGI ID: MGI:3036170
Synonyms: E2-2lox, Itf2fl
Gene: Tcf4  Location: Chr18:69344488-69687967 bp, + strand  Genetic Position: Chr18, 43.23 cM, cytoband E2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:65236
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsThe exons encoding the bHLH and C-terminal domains were flanked by loxP sites inserted by homologous recombination in ES cells. (J:65236)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tcf4 Mutation:  16 strains or lines available
References
Original:  J:65236 Bergqvist I, et al., The basic helix-loop-helix transcription factor E2-2 is involved in T lymphocyte development. Eur J Immunol. 2000 Oct;30(10):2857-63
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/18/2019
MGI 6.14
The Jackson Laboratory