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Vsx1tm1Mci
Targeted Allele Detail
Nomenclature
Symbol: Vsx1tm1Mci
Name: visual system homeobox 1 homolog (zebrafish); targeted mutation 1, Roderick R McInnes
MGI ID: MGI:3033929
Synonyms: Vsx1 delta 1-4
Gene: Vsx1  Location: Chr2:150680702-150689360 bp, - strand  Genetic Position: Chr2, 74.74 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:88182
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA genomic fragment, encompassing a portion of exon 1 and all of exons 2 through 4, was replaced with a neomycin selection cassette inserted by homologous recombination. 86 bp of the exon 1 coding region, as well as the coding region of exon 5, were left intact, however no protein was detected in homozygous mutant retinal tissue by immunofluorescence. (J:88182)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vsx1 Mutation:  0 strains or lines available
References
Original:  J:88182 Chow RL, et al., Control of late off-center cone bipolar cell differentiation and visual signaling by the homeobox gene Vsx1. Proc Natl Acad Sci U S A. 2004 Feb 10;101(6):1754-9
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory