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Loxl1tm1Tili
Targeted Allele Detail
Nomenclature
Symbol: Loxl1tm1Tili
Name: lysyl oxidase-like 1; targeted mutation 1, Tiansen Li
MGI ID: MGI:3033883
Synonyms: Loxl1-
Gene: Loxl1  Location: Chr9:58195021-58220469 bp, - strand  Genetic Position: Chr9, 31.65 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:88284
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExon 1 was disrupted by the insertion of a neomycin selection cassette inserted by homologous recombination. Protein was undetected by Western blot analysis of homozygous mutant aorta extracts. (J:88284)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 12 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Loxl1 Mutation:  32 strains or lines available
References
Original:  J:88284 Liu X, et al., Elastic fiber homeostasis requires lysyl oxidase-like 1 protein. Nat Genet. 2004 Feb;36(2):178-82
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory