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Adh5tm1Stam
Targeted Allele Detail
Nomenclature
Symbol: Adh5tm1Stam
Name: alcohol dehydrogenase 5 (class III), chi polypeptide; targeted mutation 1, Jonathan S Stamler
MGI ID: MGI:3033711
Synonyms: GSNOR-
Gene: Adh5  Location: Chr3:138443093-138455499 bp, + strand  Genetic Position: Chr3, 64.26 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:88337
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsHomologous recombination was used to replace exons 5 and 6 with a neomycin resistance gene. The deleted region encoded most of the coenzyme binding domain. S-nitrosoglutathione reductase activity was undetected in various tissues obtained from homozygous mutant mice. (J:88337)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adh5 Mutation:  12 strains or lines available
References
Original:  J:88337 Liu L, et al., Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock. Cell. 2004 Feb 20;116(4):617-28
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory