About   Help   FAQ
Chemically induced Allele Detail
Symbol: GckRgsc735
Name: glucokinase; RIKEN Genomic Sciences Center (GSC), 735
MGI ID: MGI:3033232
Synonyms: early onset diabetes, 11 RIKEN GSC, Gck11Rgsc, GckT206M, M-735, Rgsc735
Gene: Gck  Location: Chr11:5850820-5900081 bp, - strand  Genetic Position: Chr11, 3.88 cM
Alliance: GckRgsc735 page
Strain of Origin:  C57BL/6J
Project Collection: RIKEN GSC ENU Project
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
Mutation detailsC to T transition in exon 6 results in a missense mutation and a non conservative substitution for methionine for threonine at amino acid 206. This same mutation is found in human MODY2 patients. (J:88919, J:137483)
Inheritance:    Dominant
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gck Mutation:  47 strains or lines available
Original:  J:88919 Inoue M, et al., A series of maturity onset diabetes of the young, type 2 (MODY2) mouse models generated by a large-scale ENU mutagenesis program. Hum Mol Genet. 2004 Jun 1;13(11):1147-57
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
MGI 6.22
The Jackson Laboratory