Dps2^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Dps2^DBA/2J
• Name: delta power in slow-wave sleep 2; DBA/2J
• MGI ID: MGI:3033054
• QTL: Dps2 Location: Chr12:111146064-111146189 bp Genetic Position: Chr12, cM position of peak correlated region/allele: 60.94 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:68838

The authors indicated that short-wave sleep in mice can be measured by EEG activity within the 1-4 Hz range or delta power. Sleep loss results in an increase in delta power whereas excess sleep causes a decrease in delta power. The differences in delta power could be measured as a QTL in 25 strains within the BXD/Ty recombinant inbred line. QTL Dps2 was found on mouse Chromosome 12 with the closest linked marker identified as D12Mit280 with a LOD score of 3.30. The suggestive range was from 52.4 - 58.2 cM.

References

• Original: J:68838 Franken P, et al., The homeostatic regulation of sleep need is under genetic control. J Neurosci. 2001 Apr 15;21(8):2610-21
• All: 1 reference(s)