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QTL Variant Detail
QTL variant: Dps2C57BL/6J
Name: delta power in slow-wave sleep 2; C57BL/6J
MGI ID: MGI:3033053
QTL: Dps2  Location: Chr12:111179630-111179755 bp  Genetic Position: Chr12, cM position of peak correlated region/allele: 60.94 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Strain of Specimen:  C57BL/6J
Allele Type:    QTL

Mapping and Phenotype information for this QTL, its variants and associated markers


The authors indicated that short-wave sleep in mice can be measured by EEG activity within the 1-4 Hz range or delta power. Sleep loss results in an increase in delta power whereas excess sleep causes a decrease in delta power. The differences in delta power could be measured as a QTL in 25 strains within the BXD/Ty recombinant inbred line. QTL Dps2 was found on mouse Chromosome 12 with the closest linked marker identified as D12Mit280 with a LOD score of 3.30. The suggestive range was from 52.4 - 58.2 cM.

Original:  J:68838 Franken P, et al., The homeostatic regulation of sleep need is under genetic control. J Neurosci. 2001 Apr 15;21(8):2610-21
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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