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QTL Variant Detail
QTL variant: Cons4C57BL/6J
Name: consumption-saccharin intake 4; C57BL/6J
MGI ID: MGI:3033045
QTL: Cons4  Location: unknown  Genetic Position: Chr11, Syntenic
Strain of Specimen:  C57BL/6J
Allele Type:    QTL
Inheritance:    Not Specified

Mapping and Phenotype information for this QTL, its variants and associated markers


841 male mice 56-125 days of ages from 20 BXD/Ty RI strains were used to map QTLs associated with ethanol-induced conditioned taste aversion behavior. Inbred strain DBA/2J exhibits increased sensitivity to ethanol compared to C57BL/6J and decreases consumption of an ethanol-paired distinctive taste (ethanol-induced taste aversion) in a dose dependent manner. Saccharin solution drinking water was used as the paired taste in this study. Etohcta9 (P<0.01 at D11Nds1; 43.8 cM) mapped to a region on Chromosome11 spanning 40 cM - 45 cM. Etohcta9 is associated with ethanol-induced taste aversion at high-dose ethanol injection following the paired taste. Taste6 mapped to a region on Chromosome 11 spanning 23 cM - 35 cM and is associated with saccharin preference. Cons4 (P<0.01 at D11Ncvs60) mapped to 74 cM and is associated with preconditioned saccharin intake.

Original:  J:50271 Risinger FO, et al., Ethanol-induced conditioned taste aversion in BXD recombinant inbred mice. Alcohol Clin Exp Res. 1998 Sep;22(6):1234-44
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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