Aaq2^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Aaq2^C57BL/6J
• Name: alcohol acceptance QTL 2, female specific; C57BL/6J
• MGI ID: MGI:3032984
• QTL: Aaq2 Location: unknown Genetic Position: Chr12, cM position of peak correlated region/allele: 26.43 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Aaq2 affects alcohol acceptance in female animals.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:67846

23 BXD (B=C57BL/6J, D=DBA/2J) recombinant inbred (RI) strains and 218 animals from a (C57BL/6J x DBA/2J)F2 intercross were used to map sex-influenced QTLs associated with alcohol preference or alcohol acceptance. A panel of 1,550 informative markers was used for the BXD RI strains and (C57BL/6J x DBA/2J)F2 animals were typed for 101 microsatellite markers at an average spacing of 20 cM. Aaq2, a female-specific locus for alcohol acceptance maps to mouse Chromosome 12 at approximately 26 cM - 28 cM. Aaq2 is linked to alcohol acceptance at D12Mit3 and D12Mit36 in the RI strains and F2 intercross, respectively.

Suggestive loci for alcohol acceptance and alcohol preference mapped to mouse Chromosome 9 at 50.5 cM (P = 0.0047 at D9Byu4 for RI strains and D9Mit263 for F2 cross) and mouse Chromosome 2 at 30.5 cM (P = 0.0038 at Mdkc for RI strains and D2Mit367 for F2 cross), respectively.

References

• Original: J:67846 Fernandez JR, et al., Sex-exclusive quantitative trait loci influences in alcohol-related phenotypes. Am J Med Genet. 1999 Dec 15;88(6):647-52
• All: 1 reference(s)