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Chrnb3tm1Sfh
Targeted Allele Detail
Nomenclature
Symbol: Chrnb3tm1Sfh
Name: cholinergic receptor, nicotinic, beta polypeptide 3; targeted mutation 1, Stephen F Heinemann
MGI ID: MGI:3032611
Synonyms: beta3-
Gene: Chrnb3  Location: Chr8:27368711-27399730 bp, + strand  Genetic Position: Chr8, 16.0 cM, cytoband A3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:87972
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsExon 5 was interrupted by insertion of an IES-tau-lacZ cassette and a floxed neomycin resistance gene. This resulted in reduced production of mRNA transcription but did not eliminate it entirely. (J:87972)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chrnb3 Mutation:  0 strains or lines available
References
Original:  J:87972 Cui C, et al., The beta3 nicotinic receptor subunit: a component of alpha-conotoxin MII-binding nicotinic acetylcholine receptors that modulate dopamine release and related behaviors. J Neurosci. 2003 Dec 3;23(35):11045-53
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory