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Trp53tm2Glo
Targeted Allele Detail
Nomenclature
Symbol: Trp53tm2Glo
Name: transformation related protein 53; targeted mutation 2, Guillermina Lozano
MGI ID: MGI:3032598
Synonyms: p53C, p53P, pP53-R172P, Trp53515C
Gene: Trp53  Location: Chr11:69471185-69482699 bp, + strand  Genetic Position: Chr11, 42.83 cM, cytoband B2-C
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:87501
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Humanized sequence)
Mutations:    Insertion, Nucleotide substitutions, Single point mutation
 
Mutation detailsAn arginine to proline substitution was generated at codon 172 by an engineered transversion point mutation was introduced at nucleotide 515. R172P, equivalent to R175P in humans, is associated with human tumors defective in apoptosis. A single loxP site was left in intron 4 after the excision of a floxed neo cassette via cre-mediated recombination. Western blot analysis of homozygous MEFs detected full length protein at levels that exceded those of full length protein in wild-type MEFs. (J:87501)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trp53 Mutation:  205 strains or lines available
References
Original:  J:87501 Liu G, et al., Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice. Nat Genet. 2004 Jan;36(1):63-68
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory