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Targeted Allele Detail
Symbol: Adartm1.1Knk
Name: adenosine deaminase, RNA-specific; targeted mutation 1.1, Kazuko Nishikura
MGI ID: MGI:3032487
Synonyms: ADAR1-
Gene: Adar  Location: Chr3:89715022-89753446 bp, + strand  Genetic Position: Chr3, 39.19 cM, cytoband F2
Widespread apoptosis in Adartm1.1Knk/Adartm1.1Knk embryos

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:87714
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsA genomic fragment encompassing exons 12 through 15 was deleted in the germline by cre-mediated recombination of flanking loxP sites located in intron 11 and downstream of exon 15. Protein was undetected by immunostaining and Western blot analysis of homozygous mutant embryos. (J:87714)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adar Mutation:  41 strains or lines available
Original:  J:87714 Wang Q, et al., Stress-induced apoptosis associated with null mutation of ADAR1 RNA editing deaminase gene. J Biol Chem. 2004 Feb 6;279(6):4952-61
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.10
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