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Targeted Allele Detail
Symbol: Avpr1btm1Gzt
Name: arginine vasopressin receptor 1B; targeted mutation 1, Gozoh Tsujimoto
MGI ID: MGI:3029988
Synonyms: V1bR-, V1bR KO
Gene: Avpr1b  Location: Chr1:131599239-131612000 bp, + strand  Genetic Position: Chr1, 57.09 cM, cytoband E4
Germline Transmission:  Earliest citation of germline transmission: J:87707
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 3.5-kb region including the first exon and part of the first intron of the gene was replaced with a neomycin selection cassette inserted by homologous recombination. Transcript was undetected by RT-PCR analysis of homozygous mutant mice. (J:87707)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Avpr1b Mutation:  23 strains or lines available
Original:  J:87707 Tanoue A, et al., The vasopressin V1b receptor critically regulates hypothalamic-pituitary-adrenal axis activity under both stress and resting conditions. J Clin Invest. 2004 Jan;113(2):302-9
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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