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Anapc2tm2Kna
Targeted Allele Detail
Nomenclature
Symbol: Anapc2tm2Kna
Name: anaphase promoting complex subunit 2; targeted mutation 2, Kim Nasmyth
MGI ID: MGI:3029826
Synonyms: Apc2delta
Gene: Anapc2  Location: Chr2:25272478-25285915 bp, + strand  Genetic Position: Chr2, 17.12 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:87782
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA loxP site was inserted in intron 4 while a floxed and Frt flanked neomycin-Tk selection cassette was inserted in intron 1. Transient transfection with a cre-recombinase expressing plasmid results in excision of the neomycin-Tk cassette as well as exons 2-4. (J:87782)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Anapc2 Mutation:  14 strains or lines available
References
Original:  J:87782 Wirth KG, et al., Loss of the anaphase-promoting complex in quiescent cells causes unscheduled hepatocyte proliferation. Genes Dev. 2004 Jan 1;18(1):88-98
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory