Tg(MMTV-Catnb)3Pac
Transgene Detail

Summary

• Symbol: Tg(MMTV-Catnb)3Pac
• Name: transgene insertion 3, Pamela Cowin
• MGI ID: MGI:3029662
• Synonyms: MMTV-DeltaN89Beta-catenin
• Transgene: Tg(MMTV-Catnb)3Pac Location: unknown
• Alliance: Tg(MMTV-Catnb)3Pac page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(MMTV-Catnb)3Pac expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  zebrafish

  ctnnb1 (30265)

  Ctnnb1

  (MGI:88276)

• Mutation details: To express catenin beta in the epithelium of the mammary ducts, cDNA encoding Xenopus catenin beta was adjoined to a mouse mammary tumor virus long terminal repeat. The encoded catenin beta protein lacks 89 amino terminal residues, retains cadherin/catenin binding, and has increased stability in the cytoplasmic pool. Beta globin sequence and a myc epitope tag were also included in the construct. Founder mice contained a single copy of the construct and were considered "low expressing" relative to line 5. (J:69210)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:69210 Imbert A, et al., Deltan89beta-catenin induces precocious development, differentiation, and neoplasia in mammary gland. J Cell Biol. 2001 Apr 30;153(3):555-68
• All: 1 reference(s)