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Targeted Allele Detail
Symbol: Ltc4stm1Blam
Name: leukotriene C4 synthase; targeted mutation 1, Bing K Lam
MGI ID: MGI:3029254
Synonyms: LTC4S-
Gene: Ltc4s  Location: Chr11:50236461-50238532 bp, - strand  Genetic Position: Chr11, 30.4 cM, cytoband B1.1-B1.2
Germline Transmission:  Earliest citation of germline transmission: J:87909
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin gene cassette replaced 289 nucleotides from intron 1 as well as exons 2 through 4 and 32 nucleotides from intron 4. Northern blot analysis of RNA from bone marrow macrophages confirmed the absence of normal transcripts. An exon 5 containing transcript was produced however. No leukotriene C4 was detectable. (J:87909)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ltc4s Mutation:  10 strains or lines available
Original:  J:87909 Kanaoka Y, et al., Attenuated zymosan-induced peritoneal vascular permeability and IgE-dependent passive cutaneous anaphylaxis in mice lacking leukotriene C4 synthase. J Biol Chem. 2001 Jun 22;276(25):22608-13
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory