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Aco1tm1Roua
Targeted Allele Detail
Nomenclature
Symbol: Aco1tm1Roua
Name: aconitase 1; targeted mutation 1, Tracey A Rouault
MGI ID: MGI:3029223
Synonyms: IRP1-
Gene: Aco1  Location: Chr4:40143081-40198338 bp, + strand  Genetic Position: Chr4, 20.24 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:87889
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA PGK-neomycin resistance gene was inserted into exon 13. Protein product was undetectable by Western blot analysis and cytosolic aconitase activity was lost in homozygous mice. (J:87889)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Aco1 Mutation:  22 strains or lines available
References
Original:  J:87889 Meyron-Holtz EG, et al., Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis. EMBO J. 2004 Jan 28;23(2):386-95
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory