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Targeted Allele Detail
Symbol: Actc1tm1Buck
Name: actin, alpha, cardiac muscle 1; targeted mutation 1, Margaret E Buckingham
MGI ID: MGI:3029177
Synonyms: alphac-actinnlaacZ1.1, alphac-actinnlaacZ1.1delta
Gene: Actc1  Location: Chr2:114047282-114052875 bp, - strand  Genetic Position: Chr2, 57.55 cM
Germline Transmission:  Earliest citation of germline transmission: J:84604
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsSequence encoding nuclear localized lacZ was inserted immediately after the start codon via homologous recombination. A floxed neo cassette included in the targeting vector was excised via cre-mediated recombination. The expression pattern of lacZ recapitulated that of the endogenous gene. (J:84604)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Actc1 Mutation:  11 strains or lines available
Original:  J:84604 Meilhac SM, et al., A retrospective clonal analysis of the myocardium reveals two phases of clonal growth in the developing mouse heart. Development. 2003 Aug;130(16):3877-89
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory