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Anxa2tm1Kah
Targeted Allele Detail
Nomenclature
Symbol: Anxa2tm1Kah
Name: annexin A2; targeted mutation 1, Katherine A Hajjar
MGI ID: MGI:3028929
Synonyms: A2-, Anxa2-
Gene: Anxa2  Location: Chr9:69453683-69491792 bp, + strand  Genetic Position: Chr9, 38.58 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:87621
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 3 and 4 were replaced with a neomycin resistance gene inserted in antisense orientation. Reduced quantities of a smaller than normal sized mRNA were detectable in heart and lung extracts by Northern blot analysis. However, no immunodetectable protein could be identified by Western blot analysis. (J:87621)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Anxa2 Mutation:  3 strains or lines available
References
Original:  J:87621 Ling Q, et al., Annexin II regulates fibrin homeostasis and neoangiogenesis in vivo. J Clin Invest. 2004 Jan;113(1):38-48
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory