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Targeted Allele Detail
Symbol: Pou2f2tm1Bal
Name: POU domain, class 2, transcription factor 2; targeted mutation 1, David Baltimore
MGI ID: MGI:3028896
Synonyms: oct-2-
Gene: Pou2f2  Location: Chr7:25087344-25179726 bp, - strand  Genetic Position: Chr7, 13.73 cM
Germline Transmission:  Earliest citation of germline transmission: J:4555
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsA nonsense mutation was introduced in sequence encoding the POU-specific domain via homologous recombination. The stop codon was generated upstream of the POU homeo domain, into which a PGK-neo cassette was inserted. (J:4555)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pou2f2 Mutation:  12 strains or lines available
Original:  J:4555 Corcoran LM, et al., Oct-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survival. Genes Dev. 1993 Apr;7(4):570-82
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory