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Slc25a13tm1Lct
Targeted Allele Detail
Nomenclature
Symbol: Slc25a13tm1Lct
Name: solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13; targeted mutation 1, Lap-Chee Tsui
MGI ID: MGI:3028639
Synonyms: Ctrn -/-
Gene: Slc25a13  Location: Chr6:6041218-6217173 bp, - strand  Genetic Position: Chr6, 2.3 cM, cytoband A1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:87578
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 347 bp region containing exon 10 was replaced with a neomycin resistance gene inserted in opposite orientation. Absence of mRNA transcript was confirmed by Northern blot and absence of protein product by Western blot analysis. (J:87578)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc25a13 Mutation:  135 strains or lines available
References
Original:  J:87578 Sinasac DS, et al., Slc25a13-knockout mice harbor metabolic deficits but fail to display hallmarks of adult-onset type II citrullinemia. Mol Cell Biol. 2004 Jan;24(2):527-36
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory