Was^tm1Kas
Targeted Allele Detail

Summary

• Symbol: Was^tm1Kas
• Name: Wiskott-Aldrich syndrome; targeted mutation 1, Katherine A Siminovitch
• MGI ID: MGI:3028420
• Synonyms: WAS^-, WASp^-
• Gene: Was Location: ChrX:7947705-7956730 bp, - strand Genetic Position: ChrX, 3.65 cM
• Alliance: Was^tm1Kas page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87875
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The sequence from intron 4 to exon 11 was replaced with a neomycin resistance gene. Immunoblot analysis demonstrated that no protein expression occurred. (J:87875)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Was Mutation: 11 strains or lines available

References

• Original: J:87875 Zhang J, et al., Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes. J Exp Med. 1999 Nov 1;190(9):1329-42
• All: 14 reference(s)