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Wastm1Kas
Targeted Allele Detail
Nomenclature
Symbol: Wastm1Kas
Name: Wiskott-Aldrich syndrome homolog (human); targeted mutation 1, Katherine A Siminovitch
MGI ID: MGI:3028420
Synonyms: WAS-, WASp-
Gene: Was  Location: ChrX:8081453-8090498 bp, - strand  Genetic Position: ChrX, 3.65 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:87875
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe sequence from intron 4 to exon 11 was replaced with a neomycin resistance gene. Immunoblot analysis demonstrated that no protein expression occurred. (J:87875)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Was Mutation:  4 strains or lines available
References
Original:  J:87875 Zhang J, et al., Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes. J Exp Med. 1999 Nov 1;190(9):1329-42
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory