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Targeted Allele Detail
Symbol: Btlatm1Kmm
Name: B and T lymphocyte associated; targeted mutation 1, Kenneth M Murphy
MGI ID: MGI:3027713
Synonyms: BTLA-
Gene: Btla  Location: Chr16:45223705-45252895 bp, + strand  Genetic Position: Chr16, 29.52 cM
Germline Transmission:  Earliest citation of germline transmission: J:84084
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA genomic region containing exons 3, 4 and 5 was replaced with a neomycin selection cassette through homologous recombination. Northern blot analysis on splenocytes derived from homozygous mice demonstrated that no detectable transcript was expressed from this allele. (J:84084)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Btla Mutation:  19 strains or lines available
Original:  J:84084 Watanabe N, et al., BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat Immunol. 2003 Jul;4(7):670-9
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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