About   Help   FAQ
Htr4tm1Comp
Targeted Allele Detail
Nomenclature
Symbol: Htr4tm1Comp
Name: 5 hydroxytryptamine (serotonin) receptor 4; targeted mutation 1, Valerie Compan
MGI ID: MGI:3027491
Gene: Htr4  Location: Chr18:62324204-62467802 bp, + strand  Genetic Position: Chr18, 35.1 cM, cytoband D3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:87451
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe exon encoding the third transmembrane domain was disrupted by the insertion of a neomycin selection cassette inserted by homologous recombination. Autoradiography of frontal brain sections indicated an absence of functional protein in homozygous mutant brain tissue. (J:87451)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Htr4 Mutation:  18 strains or lines available
References
Original:  J:87451 Compan V, et al., Attenuated response to stress and novelty and hypersensitivity to seizures in 5-HT4 receptor knock-out mice. J Neurosci. 2004 Jan 14;24(2):412-9
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/15/2017
MGI 6.10
The Jackson Laboratory