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Targeted Allele Detail
Symbol: Htr4tm1Comp
Name: 5 hydroxytryptamine (serotonin) receptor 4; targeted mutation 1, Valerie Compan
MGI ID: MGI:3027491
Gene: Htr4  Location: Chr18:62324204-62467802 bp, + strand  Genetic Position: Chr18, 35.1 cM, cytoband D3
Germline Transmission:  Earliest citation of germline transmission: J:87451
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe exon encoding the third transmembrane domain was disrupted by the insertion of a neomycin selection cassette inserted by homologous recombination. Autoradiography of frontal brain sections indicated an absence of functional protein in homozygous mutant brain tissue. (J:87451)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Htr4 Mutation:  18 strains or lines available
Original:  J:87451 Compan V, et al., Attenuated response to stress and novelty and hypersensitivity to seizures in 5-HT4 receptor knock-out mice. J Neurosci. 2004 Jan 14;24(2):412-9
All:  5 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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