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Itgamtm1Rws
Targeted Allele Detail
Nomenclature
Symbol: Itgamtm1Rws
Name: integrin alpha M; targeted mutation 1, Richard W Stokes
MGI ID: MGI:3027319
Synonyms: CD11b-
Gene: Itgam  Location: Chr7:128062640-128118491 bp, + strand  Genetic Position: Chr7, 69.93 cM, cytoband F4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:65847
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details3' and 5' portions of exons 13 and 14, respectively, were replaced with a neomycin selection cassette inserted by homologous recombination. The insertion was expected to preclude the translation of the C-terminal, which includes the majority of the metal-binding domain and the transmembrane domain. (J:65847)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itgam Mutation:  36 strains or lines available
References
Original:  J:65847 Melo MD, et al., Utilization of CD11b knockout mice to characterize the role of complement receptor 3 (CR3, CD11b/CD18) in the growth of mycobacterium tuberculosis in macrophages. Cell Immunol. 2000 Oct 10;205(1):13-23
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory