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Targeted Allele Detail
Symbol: Irgm1tm1Gat
Name: immunity-related GTPase family M member 1; targeted mutation 1, Gregory A Taylor
MGI ID: MGI:3027112
Synonyms: Irgm1, LRG-47-
Gene: Irgm1  Location: Chr11:48861968-48871683 bp, - strand  Genetic Position: Chr11, 28.84 cM, cytoband B1.2
Germline Transmission:  Earliest citation of germline transmission: J:87535
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation details5 kb of genomic sequence were replaced with a neomycin selection cassette inserted by homologous recombination. Included in the deleted region was 0.7 kb of protein coding region. Western blot analysis of MEFs indicated an absence of protein in homozygous mutant mice. (J:87535)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Irgm1 Mutation:  10 strains or lines available
Original:  J:87535 Collazo CM, et al., Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection. J Exp Med. 2001 Jul 16;194(2):181-8
All:  26 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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