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Targeted Allele Detail
Symbol: Mre11atm1Jpt
Name: MRE11A homolog A, double strand break repair nuclease; targeted mutation 1, John H J Petrini
MGI ID: MGI:3027036
Synonyms: Mre11ATLD1
Gene: Mre11a  Location: Chr9:14784654-14837123 bp, + strand  Genetic Position: Chr9, 4.33 cM
Germline Transmission:  Earliest citation of germline transmission: J:87088
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Humanized sequence)
Mutation:    Single point mutation
Mutation detailsAn A-to-T transversion point mutation was engineered at nucleotide 1894 of the coding sequence to recapitulate a nonsense mutation identified in human patients (codon 633). This mutation results in the truncation of 75 amino acids. (J:87088)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mre11a Mutation:  37 strains or lines available
Original:  J:87088 Theunissen JW, et al., Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice. Mol Cell. 2003 Dec;12(6):1511-23
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory