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Targeted Allele Detail
Symbol: Htatip2tm1Hx
Name: HIV-1 Tat interactive protein 2; targeted mutation 1, Hua Xiao
MGI ID: MGI:3026855
Synonyms: Tip30-
Gene: Htatip2  Location: Chr7:49759115-49773975 bp, + strand  Genetic Position: Chr7, 31.44 cM
Germline Transmission:  Earliest citation of germline transmission: J:87066
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA cassette containing lacZ and neo was inserted at the endogenous locus via homologous recombination. The insertion was made 10 codons downstream of the start codon, deleting sequence from 2 exons that encode an N-terminal portion of the exon. Normal transcript was undetected in homozygous mutant mice by Northern blot analysis of RNA obtained from liver and stomach tissue. (J:87066)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Htatip2 Mutation:  7 strains or lines available
Original:  J:87066 Ito M, et al., TIP30 deficiency increases susceptibility to tumorigenesis. Cancer Res. 2003 Dec 15;63(24):8763-7
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory