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Ptprotm1Wig
Targeted Allele Detail
Nomenclature
Symbol: Ptprotm1Wig
Name: protein tyrosine phosphatase, receptor type, O; targeted mutation 1, Roger C Wiggins
MGI ID: MGI:2687220
Synonyms: GLEPP1 knockout, Ptpro-
Gene: Ptpro  Location: Chr6:137252299-137464629 bp, + strand  Genetic Position: Chr6, 66.75 cM
Glomeruli podocyte abnormalities in Ptprotm1Wig/Ptprotm1Wig mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:65903
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 3' portion of exon 2 was replaced with a neomycin selection cassette inserted by homologous recombination. Normal protein was undetected by Western blot and immunofluorescence analyses of homozygous mutant mice, however a polypeptide larger than that produced by the endogenous locus was detected at levels less than 1.2% those of wild-type. (J:65903)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptpro Mutation:  4 strains or lines available
References
Original:  J:65903 Wharram BL, et al., Altered podocyte structure in GLEPP1 (Ptpro)-deficient mice associated with hypertension and low glomerular filtration rate. J Clin Invest. 2000 Nov;106(10):1281-90
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/17/2015
MGI 5.21
The Jackson Laboratory