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Targeted Allele Detail
Symbol: Ptprotm1Wig
Name: protein tyrosine phosphatase, receptor type, O; targeted mutation 1, Roger C Wiggins
MGI ID: MGI:2687220
Synonyms: GLEPP1 knockout, Ptpro-
Gene: Ptpro  Location: Chr6:137252319-137463233 bp, + strand  Genetic Position: Chr6, 66.75 cM
Glomeruli podocyte abnormalities in Ptprotm1Wig/Ptprotm1Wig mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:65903
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 3' portion of exon 2 was replaced with a neomycin selection cassette inserted by homologous recombination. Normal protein was undetected by Western blot and immunofluorescence analyses of homozygous mutant mice, however a polypeptide larger than that produced by the endogenous locus was detected at levels less than 1.2% those of wild-type. (J:65903)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptpro Mutation:  91 strains or lines available
Original:  J:65903 Wharram BL, et al., Altered podocyte structure in GLEPP1 (Ptpro)-deficient mice associated with hypertension and low glomerular filtration rate. J Clin Invest. 2000 Nov;106(10):1281-90
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory