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Epha4rb-2J
Spontaneous Allele Detail
Nomenclature
Symbol: Epha4rb-2J
Name: Eph receptor A4; rabbit 2 Jackson
MGI ID: MGI:2687029
Gene: Epha4  Location: Chr1:77343822-77491725 bp, - strand  Genetic Position: Chr1, 39.55 cM, cytoband C1-C5
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Spontaneous (Modified isoform(s))
Mutation:    Intragenic deletion
 
Mutation detailsThis spontaneous single base pair deletion of adenine at Chr1:77,390,062 bp (GRCm38) in exon 9 results in a frameshift and premature termination, leaving wild-type sequence up to amino acid 582 then seven novel amino acids, before termination, thereby truncating the cytoplasmic sequence before the kinase or SAM domains. (J:267074)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Epha4 Mutation:  54 strains or lines available
References
Original:  J:87289 Cook SA, et al., Two spontaneous mutant alleles, rb and rb-2J, of the Epha4 gene on mouse Chromosome 1. Mouse Mutant Resources Web Site, The Jackson Laboratory, Bar Harbor, Maine. MGI Direct Data Submission. 2004;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory