Fabp1^tm1Ddsn
Targeted Allele Detail

Summary

• Symbol: Fabp1^tm1Ddsn
• Name: fatty acid binding protein 1, liver; targeted mutation 1, Nicholas O Davidson
• MGI ID: MGI:2687013
• Synonyms: L-Fabp^-
• Gene: Fabp1 Location: Chr6:71176863-71182018 bp, + strand Genetic Position: Chr6, 32.14 cM
• Alliance: Fabp1^tm1Ddsn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87278
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with GFP and a floxed neomycin cassette. Expression of either mRNA or protein product was undetectable in homozygotes. (J:87278)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fabp1 Mutation: 21 strains or lines available

References

• Original: J:87278 Newberry EP, et al., Decreased hepatic triglyceride accumulation and altered fatty acid uptake in mice with deletion of the liver fatty acid-binding protein gene. J Biol Chem. 2003 Dec 19;278(51):51664-72
• All: 12 reference(s)