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Targeted Allele Detail
Symbol: Ptk2tm1Lfr
Name: PTK2 protein tyrosine kinase 2; targeted mutation 1, Louis F Reichardt
MGI ID: MGI:2684666
Synonyms: fak-flox, FAXloxP
Gene: Ptk2  Location: Chr15:73205102-73423280 bp, - strand  Genetic Position: Chr15, 33.94 cM
Germline Transmission:  Earliest citation of germline transmission: J:86453
Parent Cell Line:  JM-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsThe second kinase domain exon was flanked 5' by a loxP site and 3' by a loxP site followed by a PGK-neomycin cassette enclosed in FRT sites and in reverse orientation. The neomycin gene was eventually removed in vivo by breeding to mice expressing FlpE recombinase in the germline. (J:86453)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ptk2 Mutation:  70 strains or lines available
Original:  J:86453 Beggs HE, et al., FAK deficiency in cells contributing to the basal lamina results in cortical abnormalities resembling congenital muscular dystrophies. Neuron. 2003 Oct 30;40(3):501-14
All:  56 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory