About   Help   FAQ
Emx1tm1(cre)Krj
Targeted Allele Detail
Nomenclature
Symbol: Emx1tm1(cre)Krj
Name: empty spiracles homeobox 1; targeted mutation 1, Kevin R Jones
MGI ID: MGI:2684610
Synonyms: emx1-cre, Emx1IREScre, Emx1-IRES-Cre
Gene: Emx1  Location: Chr6:85187438-85204462 bp, + strand  Genetic Position: Chr6, 37.21 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:78098
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Mutation detailsAn IRES-cre gene followed by an FRT flanked PGK-neomycin gene was inserted 120 bp 3' of the stop codon. The neomycin gene was later removed in vivo by crossing to an Flp recombinase expressing transgenic strain. The protein product of this gene was produced in normal quantities as confirmed by Western blot analysis. Cre recombinase expression was characterized by crossing to a Rosa26 strain. (J:78098)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Emx1     Summary of all recombinase alleles driven by Emx1.
 

Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Emx1 Mutation:  10 strains or lines available
References
Original:  J:78098 Gorski JA, et al., Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage. J Neurosci. 2002 Aug 1;22(15):6309-14
All:  156 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory