Cdkn2a^tm1(GFP)Cjs
Targeted Allele Detail

Summary

• Symbol: Cdkn2a^tm1(GFP)Cjs
• Name: cyclin dependent kinase inhibitor 2A; targeted mutation 1, Charles J Sherr
• MGI ID: MGI:2684603
• Synonyms: Arf^-, Arf^GFP, Cdkn2a^tm2Cjs
• Gene: Cdkn2a Location: Chr4:89192710-89212856 bp, - strand Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
• Alliance: Cdkn2a^tm1(GFP)Cjs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87339
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1B of the Arf gene was replaced with a GFP cassette, thereby disabling the Arf function and placing GFP under the control of the Arf promoter. (J:87339)

Expression

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdkn2a Mutation: 62 strains or lines available

References

• Original: J:87339 Zindy F, et al., Arf tumor suppressor promoter monitors latent oncogenic signals in vivo. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15930-5
• All: 21 reference(s)