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Targeted Allele Detail
Symbol: Cdkn2atm1(GFP)Cjs
Name: cyclin dependent kinase inhibitor 2A; targeted mutation 1, Charles J Sherr
MGI ID: MGI:2684603
Synonyms: Arf-, ArfGFP, Cdkn2atm2Cjs
Gene: Cdkn2a  Location: Chr4:89274473-89294619 bp, - strand  Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
Germline Transmission:  Earliest citation of germline transmission: J:87339
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 1B of the Arf gene was replaced with a GFP cassette, thereby disabling the Arf function and placing GFP under the control of the Arf promoter. (J:87339)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdkn2a Mutation:  52 strains or lines available
Original:  J:87339 Zindy F, et al., Arf tumor suppressor promoter monitors latent oncogenic signals in vivo. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15930-5
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory