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Targeted Allele Detail
Symbol: Hcn4tm1.1Jsr
Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 4; targeted mutation 1.1, Juliane Stieber
MGI ID: MGI:2684538
Synonyms: Hcn4-
Gene: Hcn4  Location: Chr9:58823512-58860955 bp, + strand  Genetic Position: Chr9, 31.8 cM, cytoband C
Germline Transmission:  Earliest citation of germline transmission: J:86988
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThis allele was derived from Hcn4tm1Jsr by breeding chimerics for that allele to Cre deleter mice expressing Cre in the gametes. This results in excision of exon 4 which encodes the pore region and transmembrane segment S6. Absence of protein product was demonstrated immunologically. (J:86988)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hcn4 Mutation:  33 strains or lines available
Original:  J:86988 Stieber J, et al., The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart. Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15235-40
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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