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Targeted Allele Detail
Symbol: Trpv5tm1Bind
Name: transient receptor potential cation channel, subfamily V, member 5; targeted mutation 1, Rene J M Bindels
MGI ID: MGI:2684536
Synonyms: TRPV5-
Gene: Trpv5  Location: Chr6:41652173-41680769 bp, - strand  Genetic Position: Chr6, 19.83 cM
Germline Transmission:  Earliest citation of germline transmission: J:86949
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 13 was deleted by cre-mediated recombination of flanking loxP sites. A neomycin selection cassette flanked by frt sites remained in intron 12. Immunohistochemical analysis of renal cortex tissue indicated an absence of protein in homozygous mutant mice. (J:86949)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trpv5 Mutation:  24 strains or lines available
Original:  J:86949 Hoenderop JG, et al., Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5. J Clin Invest. 2003 Dec;112(12):1906-14
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory