About   Help   FAQ
Trpv5tm1Bind
Targeted Allele Detail
Nomenclature
Symbol: Trpv5tm1Bind
Name: transient receptor potential cation channel, subfamily V, member 5; targeted mutation 1, Rene J M Bindels
MGI ID: MGI:2684536
Synonyms: TRPV5-
Gene: Trpv5  Location: Chr6:41652173-41680769 bp, - strand  Genetic Position: Chr6, 19.83 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86949
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 13 was deleted by cre-mediated recombination of flanking loxP sites. A neomycin selection cassette flanked by frt sites remained in intron 12. Immunohistochemical analysis of renal cortex tissue indicated an absence of protein in homozygous mutant mice. (J:86949)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trpv5 Mutation:  24 strains or lines available
References
Original:  J:86949 Hoenderop JG, et al., Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5. J Clin Invest. 2003 Dec;112(12):1906-14
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/05/2017
MGI 6.11
The Jackson Laboratory