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Trpv5tm1Bind
Targeted Allele Detail
Nomenclature
Symbol: Trpv5tm1Bind
Name: transient receptor potential cation channel, subfamily V, member 5; targeted mutation 1, Rene J M Bindels
MGI ID: MGI:2684536
Synonyms: TRPV5-
Gene: Trpv5  Location: Chr6:41652173-41680769 bp, - strand  Genetic Position: Chr6, 19.83 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86949
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 13 was deleted by cre-mediated recombination of flanking loxP sites. A neomycin selection cassette flanked by frt sites remained in intron 12. Immunohistochemical analysis of renal cortex tissue indicated an absence of protein in homozygous mutant mice. (J:86949)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trpv5 Mutation:  20 strains or lines available
References
Original:  J:86949 Hoenderop JG, et al., Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5. J Clin Invest. 2003 Dec;112(12):1906-14
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory