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Rac1tm1Tyb
Targeted Allele Detail
Nomenclature
Symbol: Rac1tm1Tyb
Name: Rac family small GTPase 1; targeted mutation 1, Victor L J Tybulewicz
MGI ID: MGI:2684419
Synonyms: Rac1flox
Gene: Rac1  Location: Chr5:143505481-143528031 bp, - strand  Genetic Position: Chr5, 82.22 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86765
Parent Cell Line:  PC3 (ES Cell)
Strain of Origin:  129S4/SvJae-Tg(Prm-cre)70Og
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsTargeting took place in ES cells homozyogus for the cre transgene Tg(Prm-cre)70Og, which expresses Cre recombinase only in haploid spermatids. A loxP site was introduced between exons 3 and 4 while a floxed PGK-neomycin resistance gene was introduced in reverse orientation between exons 5 and 6. Cre recombination in the male germline removed the neomycin gene, leaving exons 4 and 5 flanked by loxP sites. (J:86765)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rac1 Mutation:  11 strains or lines available
References
Original:  J:86765 Walmsley MJ, et al., Critical roles for Rac1 and Rac2 GTPases in B cell development and signaling. Science. 2003 Oct 17;302(5644):459-62
All:  34 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory