Sema7a^tm1Alk
Targeted Allele Detail

Summary

• Symbol: Sema7a^tm1Alk
• Name: sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A; targeted mutation 1, Alex L Kolodkin
• MGI ID: MGI:2683867
• Synonyms: null^- SEMA 7A, Sema7a-
• Gene: Sema7a Location: Chr9:57847395-57870148 bp, + strand Genetic Position: Chr9, 31.63 cM, cytoband A3.3-B
• Alliance: Sema7a^tm1Alk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87191
• Parent Cell Line: MC1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A single loxP site remained in place exon 1 as well as 1.1 kb of upstream DNA. The deleted exon includes the start codon and encodes 59 residues which comprise the entire signal sequence. (J:87191)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Sema7a Mutation: 36 strains or lines available

References

• Original: J:87191 Pasterkamp RJ, et al., Semaphorin 7A promotes axon outgrowth through integrins and MAPKs. Nature. 2003 Jul 24;424(6947):398-405
• All: 23 reference(s)