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Sema7atm1Alk
Targeted Allele Detail
Nomenclature
Symbol: Sema7atm1Alk
Name: sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A; targeted mutation 1, Alex L Kolodkin
MGI ID: MGI:2683867
Synonyms: null- SEMA 7A, Sema7a-
Gene: Sema7a  Location: Chr9:57940112-57962865 bp, + strand  Genetic Position: Chr9, 31.63 cM, cytoband A3.3-B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:87191
Parent Cell Line:  MC1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA single loxP site remained in place exon 1 as well as 1.1 kb of upstream DNA. The deleted exon includes the start codon and encodes 59 residues which comprise the entire signal sequence. (J:87191)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Sema7a Mutation:  9 strains or lines available
References
Original:  J:87191 Pasterkamp RJ, et al., Semaphorin 7A promotes axon outgrowth through integrins and MAPKs. Nature. 2003 Jul 24;424(6947):398-405
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory