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Icostm1Shr
Targeted Allele Detail
Nomenclature
Symbol: Icostm1Shr
Name: inducible T cell co-stimulator; targeted mutation 1, Arlene H Sharpe
MGI ID: MGI:2683665
Synonyms: ICOS-
Gene: Icos  Location: Chr1:60977927-61000320 bp, + strand  Genetic Position: Chr1, 30.6 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:87124
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2, which contains an immunoglobulin -V-like sequence, was replaced with a neomycin resistance gene. Absence of gene product was demonstrated immunologically. (J:87124)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Icos Mutation:  20 strains or lines available
References
Original:  J:87124 McAdam AJ, et al., ICOS is critical for CD40-mediated antibody class switching. Nature. 2001 Jan 4;409(6816):102-5
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/18/2018
MGI 6.12
The Jackson Laboratory