Icos^tm1Shr
Targeted Allele Detail

Summary

• Symbol: Icos^tm1Shr
• Name: inducible T cell co-stimulator; targeted mutation 1, Arlene H Sharpe
• MGI ID: MGI:2683665
• Synonyms: ICOS^-
• Gene: Icos Location: Chr1:61017086-61039479 bp, + strand Genetic Position: Chr1, 30.6 cM
• Alliance: Icos^tm1Shr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87124
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2, which contains an immunoglobulin -V-like sequence, was replaced with a neomycin resistance gene. Absence of gene product was demonstrated immunologically. (J:87124)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Icos Mutation: 35 strains or lines available

References

• Original: J:87124 McAdam AJ, et al., ICOS is critical for CD40-mediated antibody class switching. Nature. 2001 Jan 4;409(6816):102-5
• All: 7 reference(s)